Welcome To
Sainlos Lab
About Us
From chemical biology to neuroscience
My research sits at the crossroads of chemical biology, molecular engineering, and neuroscience, with a strong emphasis on creating innovative tools to probe and control protein–protein interactions in living systems..
We develop original approaches to overcome key methodological barriers in studying the dynamic organization and regulation of synaptic protein networks in space and time. By integrating chemical design, protein evolution, and biophysical validation, my lab has enabled the development of a new generation of customizable, live-compatible tools for targeting endogenous proteins with high specificity.
Projects
Chemical biology. Protein engineering. Directed protein evolution. Neuroscience.
BIOMIMETIC LIGANDS
We develop biomimetic peptide ligands that mimic synaptic protein complexes to dissect their interactions with scaffold proteins like PSD-95 in both cellular and structural studies
PHOTOCONTROL OF PPIs
We engineer light-sensitive versions of validated protein interaction modulators to enable precise spatial and temporal control of PPIs using light.
DIRECTED EVOLUTION OF PPI MODULATORS
We use phage-based directed evolution to generate protein domains that selectively target and modulate specific PPIs.
MOLECULAR TOOLS FOR IMAGING
We develop innovative protein labeling tools by combining chemistry and protein engineering for super-resolution imaging applications.



