Welcome To​

Sainlos Lab​

About Us​

From chemical biology to neuroscience

My research sits at the crossroads of chemical biology, molecular engineering, and neuroscience, with a strong emphasis on creating innovative tools to probe and control protein–protein interactions in living systems.. 

We develop original approaches to overcome key methodological barriers in studying the dynamic organization and regulation of synaptic protein networks in space and time. By integrating chemical design, protein evolution, and biophysical validation, my lab has enabled the development of a new generation of customizable, live-compatible tools for targeting endogenous proteins with high specificity.

Projects

Chemical biology. Protein engineering. Directed protein evolution. Neuroscience.​

BIOMIMETIC LIGANDS

We develop biomimetic peptide ligands that mimic synaptic protein complexes to dissect their interactions with scaffold proteins like PSD-95 in both cellular and structural studies

PHOTOCONTROL OF PPIs​

We engineer light-sensitive versions of validated protein interaction modulators to enable precise spatial and temporal control of PPIs using light.

DIRECTED EVOLUTION OF PPI MODULATORS

We use phage-based directed evolution to generate protein domains that selectively target and modulate specific PPIs.​

MOLECULAR TOOLS FOR IMAGING

We develop innovative protein labeling tools by combining chemistry and protein engineering for super-resolution imaging applications.

“There is another world, and it is in this one.”
― Paul Éluard

Links

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Access molecular tools created in our lab. Find out more.

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Resources​

Access to shared resources .​

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Meet the team behind the science.​

Get started and find out about our projects.​